Paris-Roubaix Challenge will take place on roads open to traffic, participants must follow traffic regulations. The organization will establish a security service throughout the course consisting of signalers (present at intersections identified as major) and motorcycles. Personal escorts in cars are strictly prohibited on the course.

It is obligatory for each participant in the Paris-Roubaix Challenge to wear a rigid helmet at all times during the event.
It is forbidden to participate in the Paris-Roubaix Challenge with a bike with some element of extension (whether or handlebar horns "handlebar triathlete"). Lay-down bikes are not allowed in Paris-Roubaix Challenge.

Medical service, which will be provided by an approved civil security association, will be able to decide on the disqualification of a competitor for medical reasons.